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G5002
Sigma
Gramicidin from Bacillus aneurinolyticus (Bacillus brevis)
Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D.
| CAS Number: | 1405-97-6 |
| EC Number: | 215-790-4 |
| MDL number: | MFCD00131232 |
Description
| Biochem/physiol Actions | Linear polypeptide antibiotic, a mixture of gramicidin A, B, C, and D. Gramicidin D, a channel-forming ionophore that flip-flops slowly across the membrane is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers. |
Properties
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Hazard Codes | Xn |
| Risk Statements | 20/21-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | MD8225000 |
References
| reference | A. Pullman, Energy profiles in the gramicidin A channel, review. Q. Rev. Biophys. 20, 173, (1987) |
| G.A. Brewer, and K. Florey (Eds.) Analytical Profiles of Drug Substances, (1979) 8, 179 | |
| Eytan, G.D., et al. J. Biol. Chem. 27, 12897-12902, (1996) | |
| Borgnia, M.J., et al. J. Biol. Chem. 27, 3163-3171, (1996) |
